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KMID : 1161420160190030281
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Journal of Medicinal Food
2016 Volume.19 No. 3 p.281 ~ p.289
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Perilla frutescens Extract Ameliorates Acetylcholinesterase and Trimethyltin Chloride-Induced Neurotoxicity
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Choi Soo-Jung
Oh Seung-Sang
Kim Cho-Rong
Kwon Yoon-Kyung
Suh Soo-Hwan
Kim Jae-Kyeom
Park Gwi-Gun
Son Seung-Yeol
Shin Dong-Hoon
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Abstract
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One of the critical features of Alzheimer's disease is cognitive dysfunction, which is, in part, due to decreases in acetylcholine (ACh). The ethanol extract of Perilla frutescens was selected for isolating the acetylcholinesterase (AChE) inhibitor based on preliminary screening. In vivo behavioral tests were performed to examine the effects of the P. frutescens extract on trimethyltin chloride-induced impairment of learning and memory in mice. A diet containing P. frutescens extract effectively reversed learning and memory impairment on the Y-maze and passive avoidance tests. To isolate the active compound from the P. frutescens extract, solvent partitioning, silica gel open column chromatography, thin-layer chromatography, and high-performance liquid chromatography were used. The AChE inhibitor was identified as rosmarinic acid.
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KEYWORD
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Acetylcholinesterase, Alzheimer's disease, Perilla frutescens, Rosmarinic acid, trimethyltin chloride
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